Decoding the Molecular Mechanisms Underlying Electronic Cigarette Toxicity in Lung, Cancer and Stem Cells Book For Free Obtain

Decoding the Molecular Mechanisms Underlying Electronic Cigarette Toxicity in Lung, Cancer and Stem Cells good book to read, this promoted by University of California, Riverside in the year 2018 is represented with you if you search book quote . good book to read, this composed by Atena Zahedi, with count of page 263 Pages. you can found description at here

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A two-tiered screen was performed to identify harmful EC products. Based on tier 1 assays, two brands were identified for further investigation. In tier 2 assays, Greensmoke exposure led to a decrease in growth rate, cytoskeletal depolymerization, adhesion defects, oxidation of mitochondrial proteins, and eventual apoptosis. Vuse exposure produced an epithelial-to-mesenchymal transition (EMT) and increased [alpha]-smooth muscle actin, a fibrosis biomarker. It also caused loss of cell-to-cell junctions, migratory behavior, internalization of junctional stabilizers E-cadherin and P120-catenin, and nuclear translocation of [beta]-catenin (dual role as a transcription factor for EMT). EMT is the initial step enabling metastasis of cancer cells, which is a concern for former smokers with a pre-existing lung tumor. Fibrosis, epithelial cell disruption, and oxidative damage can lead to chronic lung diseases.


Decoding the Molecular Mechanisms Underlying Electronic Cigarette Toxicity in Lung, Cancer and Stem Cells



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